Acromegaly through the ages


Acromegaly, Mr Punch and caricature PDF Print E-mail

Outline

Abstract

The origin of Mr Punch from the Italian Pulcinella of the Commedia dell'arte is well known but his features, large hooked nose, protruding chin, kyphosis and sternal protrusion all in an exaggerated form also suggest the caricature of an acromegalic. This paper looks at the physical characteristics of acromegaly, the origin of Mr Punch and the development of caricature linking them together into the acromegalic caricature that now has a life of it's own.

Introduction

Punch and Judy Shows are common entertainments at the seaside, fairs and for children's parties. We laugh at Mr Punch's antics without thinking about his origin. Why does he have a large nose and prominent chin? What is the reason for the hump on his back and large paunch?

Physical features of acromegaly

Pierre Marie (1853-1940) first described acromegaly in 1885, published in 18861. 'Acromegaly' literally means large extremities (Greek: áκpov = end or extremity, µéγαs = large). The hands and feet are markedly enlarged as are other parts of the body especially elongation of the lower jaw.

Acromegaly is due to oversecretion of growth hormone by the pituitary gland usually because of a pituitary adenoma. Growth hormone will induce gigantism if secreted in excess before puberty and before the bones have stopped growing, which is about the age of 17. Too much growth hormone after that age will lead to acromegaly but seldom gigantism because the long bones of the limbs have fused and can't grow any more.

The characteristic appearance of the hands in acromegaly is due to the contrast between the giant hand and the disproportionately slender arm which bears it, sometimes increased by atrophy of the muscles. The furrows of the skin are deep, the folds puffy, fingers thick 'like sausages', with the nails proportionately smaller in comparison. There is often curvature of the vertebral column and associated deformity of the chest. The lower part of the sternum projects forward as all bones of the chest are increased in size2.

This classic physical appearance is seen in Figure 1 taken from a case before Pierre Marie's publication, by Fritsche and Klebs in 18843. For a fuller clinical description refer to texts such as Grossman's Clinical Endocrinology edited by A Grossman 19924.

Peter Rhymer, Giant from Fritshce and Klebs. Two separate views. One facing forwards and one facing left so can see the left side of the body

Figure 1 A case of acromegaly before Pierre Marie published by Fritsche and Klebs3.

Origin of Mr Punch

Punch is the shortened form of the English Punchinello taken from the Italian Policianelo or Pulcinella, and the French Polichinelle, a character in the Italian Commedia dell'arte.

It is generally accepted that the whole family of Italian 'maschere', masked characters of the Commedia dell'arte, derive from the principal Oscan characters of the Roman Atellan farces and that Pulcinella is the representative of Maccus, the country bumpkin or Bucco, the comic servant. There is a gap of 1,000 years in the records between these two but the bronze statues of Maccus compare very closely with those of Pulcinella5.

The origins before Roman times are unclear but Soques A6 suggested that the character came from a nomadic people in various parts of the Orient, through to the Hebrews in Egypt and from there to Athens before being taken to Rome with many other aspects of Greek culture. Characters with similar forms are seen in Greek terracotta pottery7,8, (Figure 2). This is also seen in a comic actor acting as a slave carrying a basket to an altar, shown on a red figure phylax vase of the 4th century B.C. from the Louvre in Paris, who has acromegalic facies with a large lower jaw and protruding face9.

There continued a tradition of humpbacked and hook nosed fools in Europe in the 16th and 17th centuries10. Punchinello, (Figure 3), was introduced into England after the restoration of Charles II who gave patronage to performances by actors in 16725.

A revival in the 1790's led to the preservation of Mr Punch and as the use of marionettes waned so the glove puppet versions were popularised. These eventually became more children's toys, (Figure 4), rather than the caricatures or satirisation that took place in the 18th century11.

Antique terracotta statuette from Hollander 1912.Portrait of Mr Punch from book by Cruickshank 1881.Carte de visite of a young girl holding a doll, Mr Punch, in her right arm. Figure 2 (Right) Bückliger aus einem Satyrspiel. Antike Terrakotta aus der Gegend von Smyrna, reproduced from Höllander E, 19128. Figure 3 (Middle) Mr Punch reproduced from Cruickshank G 188110. Figure 4 (Left) Pulicinella as a child's toy from a carte de visite of a painting.

Development of caricature

Caricature comes from the Italian caricare, to overload and was given by Annibale Carracci (1560-1609) to the sketches he made of his friends which he dubbed 'caricature'. He claimed to 'grasp the perfect deformity and thus reveal the very essence of a personality' so a picture showing exaggerations of a man's most striking features would often appear more true to life than a formal portrait12. Artists and actors have always used these techniques to good effect even before being called caricature. It is likely that the actors of the Commedia dell'arte portrayed what they saw and that the audience's response depended on this. So a caricature of the local acromegalic, a little slow, fat paunch, large nose, hump-back and strange protruding chest would certainly strike a familiar chord.

Dumas13 wrote that "L'aspect caricatural du visage de l'acromégalique offrait une pâture toute trouvée aux peintres et aux dessinateurs satiriques." and that Honoré Daumier had a special predilection for this; the tendency of the cartoonist to 'acromegalise'.

Edward Lucie-Smith14 notes how during the renaissance the possibility of drawing characters to make them look grotesque reflected back to the illustration of dwarfs and pygmies in the classical period. He suggests a psychological explanation that 'Whatever was depicted was thus literally diminished and made grotesque'. The easiest person to make fun of is someone different from the 'normal' whether due to size, shape or deformity.

Caricatures in many of today's newspapers have the tendency to acromegalise their subjects for example that of Pope John Paul II in The Observer15 and many that can be seen every day. However, it is important to differentiate between the medical caricaturisation of an acromegalic16 and the acromegalisation of the famous and infamous.

Acromegaly and Mr Punch

Soon after Pierre Marie gave the name, acromegaly, attention was drawn to the resemblance between Pulcinella and acromegalics6,17.

A comparison between Figure 1 and Figures 3 and 4 shows the classic enlarged lower jaw, hooked nose, kyphosis and sternal protrusion of acromegalics exemplified in the over-exaggeration of these features in Mr Punch. In some early engravings Mr Punch is also shown with a large paunch. This is due to the kyphosis of the spine which causes the costal margin to become more prominent and approximate more to the pelvis resulting in the abdomen protruding forwards. These features suggest the character was used to portray the acromegalic form. Dr. Leonard Mark, who wrote an autobiography of his own life as an acromegalic18, also suggested a connection between Mr Punch's hitting people over the head and the debilitating headaches untreated acromegalics suffer from.

Clinicians soon applied the epithet 'Punch-like' to their patients: 'The neck was thick, and there was a general tendency to kyphosis in the upper dorsal region, and a tendency to protrusion of the lower end of the sternum, so that a Punch-like figure was developed.'19 and ' . . . the sternum was pushed forward, "Pulcinello chest." 20 taking the characterisation full circle.

Caricature or acromegalic caricature

It is difficult to discern whether illustrations actually show a true portrait or are caricatures. Some examples of terracotta statuettes in the collection of the Louvre in Paris, including ten acromegalics, are accurate medical illustrations of conditions7 others examples are clearly exaggerations.

Höllander8 questions whether all of the terracotta heads supposed to be of acromegalics can be given the diagnosis of acromegaly, as many are more like caricatures, following the fashion of the fool character of the Atellan comedies21. In 1915 Coues22 viewed the Flemish faces, in the Grimani Breviary23 as possibly acromegalic. These are, however, more likely the natural variation in facial physiognomy purely portraits of people seen by the artist in the 15th century. In the same way the hereditary anomalies of the Hapsburg and Ptolemaic lower jaws are acromegaloid not acromegalic24.

Conclusion

The strong resemblance between acromegalics was noticed very early on 'There are very few diseases all cases of which appear to present such a strong family likeness' Hutchinson W 189825.

I can remember recognising an acromegalic for the first time when traveling on a bus as a student. It is quite likely the familial appearance of acromegalics enhanced its popularity for caricaturists and satirists in ancient and mediaeval Europe just as its photogenicity has made it a commonly photographed subject this century. Art mimics life too often for there not to be a grain of truth to the acromegalic origin of Mr Punch but that does not mean that all historical acromegaloid caricatures are caricatures of acromegalics.

The history of Mr Punch has been the institutionalisation of a caricature. Continual reinforcement has entrenched the caricature so that it has taken on a life of its own beyond its origins. However, any connection between acromegalics and Mr Punch, and the risk of ridicule, is unlikely to continue in the developed world as individuals are now diagnosed and treated before the classic 'acromegalic' changes occur.

Acknowledgments

Dundee Public Library, Ninewells Hospital and Medical School Library, Dundee, National Library of Scotland and Pickford House Museum, Derby Art Gallery & Museum for help in my research.

Resources

Weblinks

Centre for the Study of Cartoons and Caricature http://library.kent.ac.uk/cartoons/

References

  1. Marie P. Sur deux cas d'acromégalie; hypertrophie singulière non congénitale des extrémités supérieures, inférieures et céphalique. Rev de Med 1886; 6: 297-333. Transl London: New Sydenham Society, 1891.
  2. Sternberg M. Acromegaly. London: New Sydenham Society, 1899.
  3. Fritsche, Klebs E. Ein beitrag zur pathologie des riesenwuchs. Klinische und pathologischananatomische untersuchungen. Leipzig: FCW Vogel, 1884.
  4. Grossman A, ed. Clinical Endocrinology. Oxford: Blackwell Scientific Publications, 1992.
  5. Encyclopaedia Britannica 1969; 866-7.
  6. Soques A. Maccus, polinchinêlle et l'acromégalie. Nouv Iconogr de la Salpêtriere 1896; 9: 375-80.
  7. Gourevitch D Gourevitch M. Terres cuites hellénistiques d'inspiration médicale au musée du louvre. Presse Méd 1963; 71: 2751-2.
  8. Holländer E. Plastik und Medizin. Stuttgart: Enke, 1912; 351-4.
  9. Green P. A Concise History of Ancient Greece. London: Thames & Hudson Ltd, 1973; 155.
  10. Cruickshank G. Punch and Judy. London: George Bell & Sons, 6th edn, 1881.
  11. Ayres J. British Folk Art. London: Barrie and Jenkins Ltd, 1977: 56-8.
  12. Toms K. Origins of Caricature. Museum of Newspapers and Caricature. Personal Communication.
  13. Dumas P. L'acromégalie-gigantisme avant Pierre Marie. Neurochirurgie 1973; 19 (Suppl 2): 13-22.
  14. Lucie-Smith E. The Art of Caricature. London: Orbis Publishing, 1981.
  15. Levine D. Caricature: Pope John Paul II, The Observer 1982; 25th April.
  16. Armstrong R. The role of caricature in medicine. J Audiovis Media Med 1993; 16: 165-9.
  17. De Souza-Leite JD. De l'acromégalie. Maladie de Marie. Thèse de Paris, 1890. Transl, London: New Sydenham Society, 1891.
  18. Mark LP. Acromegaly: A personal experience. London: Baillière Tindall & Cox, 1912.
  19. Ferrier D. Acromegaly. Lancet 1910; ii: 1765-6.
  20. Jewesbury RC. A case of acromegaly. Lancet 1913; i: 1169.
  21. Weinberg SJ. Gigantism and acromegaly. Ann Med Hist 1931; 3: 650-73.
  22. Coues WP. Early pictures of acromegaly. Boston Med Surg J 1915; 172: 159.
  23. Das Brevarium Grimani. (Facsimile Publication). Leyden: AW Sijtaoff, 1903-8; 14: No 1571.
  24. Wells C. The Ptolemaic Jaw. Appl Therapeutics 1967; 9: 768-71.
  25. Hutchinson W. The pituitary gland as a factor in acromegaly and giantism. New York Med J 1898; 72: 89-100.
Bryson D. Acromegaly, Mr Punch and caricature. Journal of Audiovisual Media in Medicine 1996; 19 (3): 119-122 pdf file 1Mb

 

 
Acromegaly through the ages PDF Print E-mail

Dicky is said to be ‘one of the most deformed pieces of mortality I ever saw, and of most uncouth manner of speech.’ Rowntree A The History of Scarborough

In looking at early cases of acromegaly it is necessary to remember the role played by artistic license. Is the subject really an acromegalic? Is the portrait an accurate representation or the artists personal portrayal or even a caricature? 

Acromegaly and early man

The links between acromegaly and early man range from possible to highly improbable, from atavistic theories to being duped by a scientific fraud.

Early atavistic theories of causation

Piltdown man

Neolithic acromegalic

Early atavistic theories of causation

Early after the differential diagnosis of acromegaly came publication of Darwin’s Origin of Species (Check date)

Huxley on Neanderthal re: acro

fig 177 in Keith pg 487, 1937.

Campbell (1896) 962 and Keith A (1911) 961 both suggest a direct resemblance between acromegalic facies and neanderthal or man’s ape-like progenitors. The atavistic view saw acromegaly as a reappearance of ancestral traits or a reversion to those characteristics. The double possibility of throwing some light on the structure of man’s immediate ancestors and finding a cause for acromegalic occurrence in man are adequate stimulation for these and similar papers.

Face of a gorilla.Hand of a gorilla. Face of an acromegalicHand of an acromegalic

Piltdown man

This scientific oddity only qualifies as an illustration through Adami saying that “Sir Auckland Geddes , has impressed upon me that the earliest known human fossil is pathological, pointing out that the remarkable thickness of the Piltdown skull, coupled with the characteristic outline of the temporal ridge can only find their explanation by a diagnosis of acromegaly, and suggesting that it is thanks to this disease and its results that we owe the survival of these remains through the ages.”

Not to suggest that acromegaly is a zymotic disease (a disease regarded as caused by the multiplication of germs introduced from outside)

This contention obviously looks ridiculous in hindsight but with the difficulties experienced in reconciling the pieces of the puzzle using the pathology of acromegaly is a useful if erroneous escape. (Adami’s book is oddly rather Lamarckian in emphasis.)

Atkinson FRB. 1936

". . . Sir Auckland Geddes considers the Piltdown skull shows by its configuration it belonged to an acromegalic and dates therefore from 100,000 years, there is not sufficient evidence to be dogmatic on the point.” (cf Adami JG 1918)

Neolithic acromegalic

Brothwell 1982

A case of acromegaly in a neolithic individual from switzerland has been described by Schlaginhaufen (1925), but the diagnosis has since been disputed.

(Sigerist 1951)

A case of neolithic acromegaly from switzerland has been described by O. Schlaginhaufen but his diagnosis has been contested and must remain uncertain since it is based on the examination of an incomplete femur only.

Schlaginhaufen O 1925

Possible neolithic case of acromegaly (Schlaginhaufen, O 1925).

Early history

King Saul (Historical dates needed)

Levin (1965) has suggested that King Saul's raging headaches and missing David with his javelin could be due to the gradual increase in size of a pituitary tumour.

Need quotes from bible (1 Samuel 4:2, 9:2, 18:11, 19:10)

Roman period - Marcus Antonius

Cheselden W 1723 Cheselden W 1712

Bones found in an urn marked "Marcus Antonius in the place of the Roman camp near St Albans." Cheselden used his camera obscura for his drawings of the bones in his publication Osteographia.

Mediaeval period

12th century - Homo Gardarensis

Perkins M (1931) - also use re: Giants chapter and re: possible hereditary overactive pituitary gland.

"It is certain that descendants of Ulf the fearless settled in Greenland, because soon after its discovery, fourteen ships reached that land from Borgafjord of Skallagrim's settling, through whom he derived from Ulf: it is quite possible that the Gardarik skulls include some of Ulf's descendants."

The Gardar skull may be an extreme example of this "berserker" stock but similar less pronounced specimens have been recovered in the same cemetery (Pederson PO 1944).

Pederson 1944 -  Views of skull Gardar VII Shape of cranium Gardar VII, right lateral view of cranium and lateral view of right lower jaw.
See also other images Page 1 Page 2 Pederson 1944 - Right lateral view of skull Gardar VII Pederson 1944 - Lateral view of lower jaw Gardar VII

Keith A (1931) 12th century skull, Gardar Greenland evidence from vault and mandibular fragments. Brøste K et al ( )

Perkins M (1931) Acromegaly in the far north. Nature no. 3229; 128: 491.

Brøste K Fisher-Møller Pederson PO The mediaeval norsemen at Gardar. Meddon Grønland 89 No 3.

Keith A. (1931) New discoveries relating to the antiquity of man. London p. 483-99. Chapter 32 - The problems raised by the discovery of Homo Gardarensis.

Perkins M. (1931) Acromegaly in the far north. Nature 128 (No 3229) p. 491-2.

Late mediaeval - Kloster monastery

Isager K. (1936) Skeleton excavated from graveyard late mediaeval monastery, Kloster , Copenhagen.

Isager K. (1936) Skeletefundene ved øm Kloster. Copenhagen.

13th Century - Figure on Reims cathedral

This carved figure bears the hallmarks of acromegaly, with hand held to weary head possibly a sign, as fellow sufferer Dr Mark suggests, of the severe headache afflicting the woman (Mark LP. 1912, 1914). Unfortunately Atkinson reports (1930) being unable to relocate this statue due to then damage inflicted by the 1st World War.

" . . . . of special interest at the present moment, is a carved figure of a woman, dating from the thirteenth century, which was placed high up on one of the flying buttresses of Reims Cathedral. This statue has been described as pointing out in a striking way the physical characteristics of acromegaly. As it stood on the north side of the cathedral, which was the one which suffered least from the early bombardment of Reims leaves one little hop that this interesting relic of the past, after weathering the storms of seven centuries, is not now to be reckoned amongst the innocent victims who have fallen before the spread of German Kultur." Mark LP 1914

Mark Lp 1912, Figure seen on Reims Cathedral

Figure seen on Reims Cathedral by Leonard Mark (1912).

Mark LP. (1912) Acromegaly: A personal experience. London: Baillere, Tindall & Cox.
Mark LP. (1914) A case of acromegaly 200 years ago. Lancet ii, 1412-3.
Atkinson FRB. (1930) Acromegaly. London:

Ming Tschu Yuan Chang b.1368

The founder of the Ming dynasty (1368 - 1644), Tschu Yuan Tschang, is shown in his portraits to have characteristics of acromegaly in the face, especially the elongation of the jaw which hints at malocclusion of the teeth. Under his rule China prospered, so that the case is an exception from the commonly accepted rule that sufferers of acromegaly are not capable of much physical or mental exertion when the disease is fully developed (Seiffert G 1937).

Seiffert G 1937 - Ming Tschu Yuan ChangSeiffert G 1937 - Ming Tschu Yuan Chang

Ming Tschu Yuan Chang, note especially the elongation of the mandible (Seiffert G 1937).

 15th and 16th Century

Das Brevarium Grimani

Das Brevarium Grimani - Flemish faces

Flemish faces, acromegalic or acromegaloid? Das Brevarium Grimani (1903-08, Plate no 1571).

Wm Pearce Coues noticed the acromegalic type facies in this breviary, following Dr Leonard Mark's article on Richard Dickinson (Mark LP 1914) and the figure on Reims Cathedral (Mark LP 1912), and described the appearance of one of its plates as follows;

" . . . an exhibition of miniatures at the Boston Public Library from the Grimani Breviary is of interest. This breviary contained nearly 2,000 pages and was the masterpiece of the Flemish miniature paintings. It dates from the 15th century. Some of the paintings are thought to be by Hans Memling. No 1571 is the picture that interests us in this connection. It is of St Catherine disputing with the doctors (3rd century). Without doubt, contemporary Flemish faces (15th century) were the models. This picture is by an unknown artist. In the group around St Catherine are two figures which stand out unquestionably as typical acromegalics the immense prognathous jaw, and large face in one figure being particularly interesting. One of the lower figures had also typical facial characteristics. In other fifteen pictures, some of the sacred subjects, some of profane, there is no hint of an acromegalic face, though the broad features of the Flemish type are faithfully portrayed." (Coues WP 1915)

Whether these faces are strictly acromegalic is debatable, especially in view of the cosmopolitan trade in Belgium with a wide variety of ethnic facial characteristics. The close-up below shows the faces clearly but I leave the decision as to whether any are 'acromegalic' to the viewers imagination and safely term the facies as acromegaloid.

Das Brevarium Grimani
Flemish faces, acromegalic or acromegaloid?

1425 - 1474 Henry IV of Castille "The impotent"

Notes Marañon G - Need to access images, engraving, seal.

Marañon G Essayo biologico sobre Enrique IV de castilla y su tiempo, Buenos Aires, 3rd ed. Coleción Austral.

Gregorio Maranon http://www.fund-gregorio-maranon.com/001/pag1i.htm

17th and 18th Century

1670 - 1738 Richard Dickinson

Dr Leonard Mark (1914) reported on 'A case of acromegaly 200 years ago" stimulated by interest in his biography "Acromegaly a personal experience" (Mark LP 1912) from Scarborough antiquarian Dr Everley Taylor. Dr Taylor recognised the characteristics of acromegaly in Richard Dickinson who ran a spa in Scarborough in the 18th century.

Richard Dickinson Illustrations of Richard Dickinson from the collection of Sir Meredith Whittaker (Mark LP 1914) . Richard Dickinson

An account of Richard Dickinson is included in the manuscript diary of Richard Du Cane, junior, 1726-29 (Addison W 1951).

'Wednesday, 26th October 1726: This morning went to the Spaw, which was built by Richard Dickinson and now kept by him. He is a very deformed man. From thence to the Castle, which is very large and high. Also we were in the Church, which is very large; but when the Castle was battered, some of that was beat down in Oliver's time.' (Addison W 1951)

Addison (1951) also records the description of Dicky, from Arthur Rowntree, as being 'one of the most deformed Pieces of Mortality I ever saw, and of the most uncouth manner of speech.' However this must have worked to Dicky's benefit as he is also recorded as having built two houses for visitors, ran a Spa and from Mark's comments he was very popular with painters and artists from plates to engravings 'He did not escape the notice of painters and poets of his time, and there are not less than seven original resemblances of him preserved by different artists, and copies of the same innumerably multiplied' so perhaps his deformity was useful in enhancing his income and notoriety.

Knaggs RL(1935) also includes an image of Richard Dickinson in his paper on acromegaly.

Richard Dickinson Richard Dickinson from a picture in the Royal College of Surgeons Museum (Knaggs RL 1935)

Portraits in the National Portrait Gallery Archive Collection

Richard Dickinson (1669-1739), 'Governor of Scarborough Spaw' Sitter in 2 portraits NPG D1759 Richard Dickinson after Hans Hysing mezzotint http://www.cogapp2.com/NPGHome/live/search/person.asp?LinkID=mp55668
NPG D1760 Richard Dickinson

Scarborough

History of Scarborough http://www.history.scarborough.co.uk/

North Yorkshire County Library, Vernon Road,  Scarborough, Y011 2NN 01723 364285. Scarborough Borough Council: Scarborough Borough Council (e-SBC) SBC Economic Development Office http://www.e-sbc.co.uk/

19th Century

1856 Dr Hugh Diamond "The face of madness"

Page of portraits from the work of Dr Hugh Diamond 1856. Woman with acromegaly is sitting in a chair and shows typical acromegalic characteristics of a large jaw and masculine facial features

Dr Hugh Diamond's photographs of patients, Female department of Surrey County Lunatic Asylum (Gilman SL 1977).

References Gilman SL 1977, Taurek R 1980, Diamond HW 1856, Connolly J 1858.